What is the most important step in preventing central venous catheter related sepsis?

Thorough handwashing is paramount in preventing central venous catheter-related sepsis because it significantly reduces the risk of introducing pathogens into the bloodstream. Proper hand hygiene before the insertion and maintenance of the catheter directly impacts the likelihood of infection. It removes transient flora and reduces the number of microorganisms on the hands, which can then contaminate the catheter or the insertion site.

While using sterile gloves and regular dressing changes are also important practices, they are most effective when combined with robust hand hygiene. Antibiotic prophylaxis is beneficial in certain circumstances but does not replace the fundamental need for effective handwashing in preventing infections. Overall, hand hygiene forms the first line of defense against sepsis in patients with central venous catheters.